How to Test for Leaky Gut (The Gold Standard Test)

Aug 01, 2024

Leaky gut, clinically known as intestinal permeability, is a condition that has gained significant attention in recent years due to its potential impact on overall health and well-being. The intestinal lining’s main job is to absorb nutrients while preventing harmful substances from entering the bloodstream. When this lining becomes compromised, it can lead to various health issues.

WHAT IS LEAKY GUT?

Leaky gut occurs when the tight junctions between the cells of the intestinal wall become loose or damaged. This allows substances like toxins, undigested food particles, and bacteria to leak through the intestinal barrier and enter the bloodstream. In response, the immune system may become activated, leading to inflammation and potentially contributing to a range of symptoms such as digestive issues, food sensitivities, autoimmune conditions, and more.

THE IMPORTANCE OF TESTING FOR LEAKY GUT

Diagnosing leaky gut based on symptoms alone can be challenging because its symptoms overlap with many other conditions. Therefore, having a reliable test to assess intestinal permeability is key for accurate diagnosis and effective treatment.

THE GOLD STANDARD TEST: LACTULOSE MANNITOL TEST

Among the various methods available, the Lactulose Mannitol Test is widely considered the gold standard for assessing intestinal permeability. Here’s how it works:

Test Procedure:

Patients consume a solution containing two types of sugars: lactulose and mannitol.
Lactulose is a larger molecule that normally should not pass through the intestinal barrier.
Mannitol is a smaller molecule that is easily absorbed under normal conditions.

Collection of Urine Samples:

Over a period of several hours (usually 6 hours), urine samples are collected.
The ratio of lactulose to mannitol in the urine is then measured.

Interpretation:

A higher ratio of lactulose to mannitol suggests increased intestinal permeability.
This indicates that larger molecules (like lactulose) are passing through the intestinal lining, which is a sign of leaky gut.

ADVANTAGES OF THE LACTULOSE MANNITOL TEST

Accuracy: It provides a quantitative assessment of intestinal permeability, offering valuable insights into the severity of the condition.
Non-invasive: The test involves drinking a solution and collecting urine samples, making it relatively simple and safe for patients.
Diagnostic Utility: It helps healthcare providers differentiate between leaky gut syndrome and other gastrointestinal conditions with similar symptoms.
Cost: In Australia this test costs $160, which makes it an achievable price-point for many.

WHY TESTING IS IMPORTANT

Can’t we just assume we have leaky gut if we have symptoms?

While the desire to label ourselves with leaky gut and immediately start drinking bone broth is strong - this is not the answer.

Science tells us that a leaky gut takes 3-6 months to heal, AND the clinically researched dose of nutrients that are effective is quite high.

For example 15-30g/day of glutamine is what has been used in scientific papers. This is quite a lot! Especially if taken for 3-6 months. (** please note glutamine is not recommended if you have epilepsy).

Other nutrients such as zinc carnosine, and Saccharomyces boulardii CNCM I-745 have also shown to be effective at the right dose.

In the realm of gut health, diagnosing and treating leaky gut effectively is key for improving overall health outcomes. The Lactulose Mannitol Test stands out as the gold standard due to its reliability, non-invasiveness, and diagnostic utility. If you suspect you may have leaky gut or are experiencing symptoms such as chronic digestive issues or food sensitivities, consulting with a qualified practitioner who can administer and interpret this test is recommended.

By understanding the role of intestinal permeability, testing for it, and treating it effectively, we can take proactive steps towards restoring gut health and enhancing overall well-being.

Brooke x

If you are ready to resolve your gut issues, please get in touch by booking in a Discovery Call HERE.